The prestigious 2025 Lasker Awards honored foundational discoveries in molecular biology and transformative medical research. Dirk Görlich and Steven McKnight received the Basic Medical Research Award for revealing the functions of low-complexity domains in protein sequences, vital to intracellular transport and organization. Michael Welsh and colleagues earned the Clinical Medical Research Award for developing a triple-drug combination that dramatically improved cystic fibrosis treatment, revolutionizing patient outcomes. These accolades emphasize critical advances in understanding cellular mechanisms and delivering life-saving therapies.