Researchers at Indiana University reported a chemical strategy that restores antibiotic activity against resistant bacteria, presenting a potential adjunct to existing antibiotics. The study outlines a small‑molecule intervention that targets resistance mechanisms to sensitize pathogens to previously ineffective treatments. The work, originating from IU Bloomington’s biochemistry lab, provides a non‑biologic route to address antimicrobial resistance—a major public‑health and commercial challenge. If reproducible in vivo and amenable to medicinal chemistry optimization, the approach could yield adjuvants for combination therapies and revive utility of legacy antibiotic classes.