Integrated Biosciences has developed a novel optogenetic screening platform enabling precise control and high-throughput interrogation of biological systems, facilitating discovery of selective integrated stress response modulators. A recent publication in Cell demonstrated the platform’s application in identifying ISR-potentiating compounds that sensitize cells to apoptosis without cytotoxicity. The platform’s ability to deliver pathway-specific activation offers unprecedented precision and provides a powerful tool for age-related drug discovery and antiviral therapeutic development.