Integrated Biosciences published a Cell paper detailing a novel optogenetic screening platform that enables millisecond precision activation of the integrated stress response (ISR) pathway, facilitating high-throughput drug discovery. Screening over 370,000 compounds, researchers identified ISR-modulating molecules that sensitize stressed cells to apoptosis without toxicity across cell types. This modular platform allows precise pathway interrogation, overcoming limitations of traditional drug screens, and reveals compounds with unprecedented mechanisms targeting neurodegeneration, cancer, and viral infections.