Biotech startup Integrated Biosciences introduced an innovative optogenetic screening platform integrating chemistry and AI to discover small molecule modulators with precision. Demonstrated through activation of the integrated stress response pathway, the platform identified compounds sensitizing cells to apoptosis with antiviral effects in vivo against ocular herpesvirus. This approach offers unprecedented control and clarity for real-time pathway-specific drug screening, overcoming limitations of traditional phenotypic assays and facilitating high-precision therapeutic discoveries for age-related diseases.