Clinicians and researchers at the University of Warwick, University Hospital North Midlands NHS Trust, and Imperial College London used digital twin technology to evaluate a newly proposed transition protocol to airway pressure release ventilation (APRV) for acute respiratory distress syndrome. The effort assessed how patients might respond during switching—a decision point that can affect outcomes in mechanically ventilated critical care. Digital twins, in this context, refer to computational patient models intended to simulate physiological responses and support protocol design and testing before broader clinical rollout. The reported work provides a framework for using model-based evidence to reduce uncertainty when translating ventilation strategies. For ICU practitioners and medical-device developers, the use case signals expanding demand for model-driven decision support in respiratory care where standardization and timing remain critical.