Scientists at the University of Cologne developed 'DynaTag,' a refinement of the CUT&Tag assay that reduces salt concentration to capture transient transcription factor binding on DNA. This methodological tweak enhances chromatin profiling capabilities, allowing the assay to detect specific factors like c-Myc in single-cell models of small-cell lung cancer. This breakthrough is poised to advance epigenetic research and precision oncology by enabling detailed transcription factor activity mapping.