Two complementary studies published in Nature Biotechnology detail novel immunological strategies to combat methicillin-resistant Staphylococcus aureus (MRSA) infections by inducing bacterial calcification. Researchers developed antibody–polysialic acid conjugates that promote calcium deposition on MRSA surfaces, effectively encasing bacteria in a calcified shell to boost immune recognition and clearance in mice. This biomimetic tactic offers a promising new avenue for treatment of chronic, multidrug-resistant staphylococcal infections, circumventing traditional antibiotic resistance mechanisms and enhancing immunogenicity for improved therapeutic outcomes.