Chuo University researchers achieved landmark mass production of artificial cells containing model nuclei using microfluidic platforms, replicating eukaryotic DNA condensate structures with functional protein synthesis. Yale scientists enhanced multiplex gene editing precision, tripling effective edits while minimizing off-target effects. Novel gene therapy methods utilize spatial genome rearrangements to reactivate dormant genes. Advances in Kemp eliminase enzymes exemplify fully computational enzyme design, pointing toward a transformative era in synthetic biology and targeted therapeutic development.