Leading academic cancer centers showcased groundbreaking radiation therapy advances at the 2025 ASTRO Annual Meeting. UCLA Health highlighted personalized radiation using genomic adjusted radiation doses for HPV-positive throat cancer and novel stereotactic body radiation techniques for prostate cancer. MD Anderson Cancer Center presented long-term data showing stereotactic body radiotherapy matches surgery outcomes in early-stage lung cancer. University of Cincinnati and Sylvester Comprehensive Cancer Center revealed improvements in radiation protocols for head and neck and hepatocellular carcinomas, promising enhanced treatment efficacy and reduced toxicity.