Technological advancements are improving the detection and characterization of complex diseases. Dovetail Genomics introduced LinkPrep™, combining DNA sequence with 3D genome architecture analysis to detect structural variants affecting gene regulation, particularly in cancer. Novel MRI radiomics techniques offer enhanced glioblastoma survival prediction by integrating imaging and biological data. Additionally, megavoltage CT-based radiomic analysis tracks femoral bone changes during helical tomotherapy for prostate and rectal cancer, improving treatment monitoring.