Cutting-edge research leverages artificial intelligence and bioinspiration to engineer advanced hydrogels with superior adhesive properties. Inspired by marine organisms such as barnacles and mussels, researchers have integrated sticky protein mimics into hydrogels and used machine learning to design formulations with ultra-strong underwater adhesion, demonstrated to retain mechanistic strength for over a year in saline environments. Other novel injectable hydrogels engineered for scarless urethral repair show promise in regenerative medicine, facilitating tissue regeneration without fibrosis. Such biomaterials hold transformative potential for medical, industrial, and environmental applications requiring robust adhesion in wet conditions.