Cutting-edge artificial intelligence is transforming neuroscience and genomics by enabling unprecedented resolution in brain mapping and variant interpretation. Researchers at UCSF and the Allen Institute developed CellTransformer, an AI model using transformer architecture akin to ChatGPT, to produce a detailed map delineating 1,300 regions and subregions of the mouse brain, enhancing insight into spatial tissue organization. Complementary studies introduced novel computational frameworks to improve genetic variant interpretation, thereby advancing precision medicine. These collaborative technological strides are accelerating understanding of complex biological systems.