Groundbreaking work in genome editing achieved megabase-scale precision using Programmable Chromosome Engineering (PCE) by Chinese researchers, advancing capabilities in plants and higher organisms. Additionally, the development of the Platinum Pedigree benchmark greatly enhances genetic variant detection accuracy, covering complex genomic regions and structural variants through a family pedigree validated approach. These innovations significantly improve the resolution and reliability of genomic editing and analysis, crucial for therapeutic development and human genetics research.