Process intensification and advanced analytics are transforming biologics manufacturing. Lonza and Sartorius collaboration highlights Raman spectroscopy as an inline process analytical technology (PAT) to improve downstream purification efficiency and control, especially during ultrafiltration/diafiltration steps. Thermo Fisher’s high-throughput platform and robotic automation have enabled rapid downstream chromatography development, increasing purification runs to over 100 per week, significantly shortening timelines. These advances maintain product quality, reduce costs, and increase productivity, meeting rising demands for efficient therapeutic antibody and viral vector production.