A spatial genomics approach called Slide-GoTags aims to improve precision in cancer immunotherapy by showing where neoantigen tumor cells and T-cell receptor (TCR) interactions colocalize within the same tissue slice. The platform combines single-nucleus RNA sequencing, targeted transcript genotyping, and TCR sequencing from a single frozen sample. By anchoring immune recognition to spatial context, Slide-GoTags targets a known limitation of standard biopsy workflows—namely that tumor-immune interactions are highly localized and may explain why immunotherapy responses vary between patients. — Key takeaway: the method is positioned as a translational bridge toward better biomarker interpretation without relying solely on bulk measurements.