Emerging research enhances understanding of immune regulation and cancer immunotherapy. A novel genome-wide CRISPR screen in human natural killer cells identified key genetic regulators to improve CAR NK cell therapy. Regulatory T cells expressing a FOXP3 splice variant promote antitumor immunity by shifting toward a T helper-like phenotype. Investigations also reveal mechanisms driving cisplatin resistance via SOX2 and pathways linking adipocyte IL6 to triple-negative breast cancer progression through STAT3/NF-κB crosstalk.