A melanoma immunology study mapped a key immune microenvironment interaction by showing how tumor-resident T cells and dendritic cells coalesce into a distinct functional unit. The Nature Communications work points to a structured immune collaboration within tumors, tightening mechanistic links that could inform next-generation immunotherapy combinations. In another cancer-directed immunology finding, researchers reported that anti-CD4 therapy can boost CD8+ immunity and halt lung cancer progression in models complicated by pulmonary fibrosis. The reported mechanism centers on engaging CD4+ T cells to enhance antitumor CD8-mediated responses, expanding the set of immune-cell targets under consideration in fibrosis-linked oncology.