A study in glioma preclinicals found that spatially fractionated mini-GRID radiotherapy reduced senescence markers and persistent DNA-damage signals while preserving anti-tumor effects compared with conventional radiotherapy. The data suggest that altering radiation delivery patterns can shift downstream tumor-cell biology. In parallel, research identified an immune evasion mechanism in esophageal cancer: SIRPα produced by cancer cells fuels both tumor growth and T-cell exhaustion, potentially explaining resistance to anti-PD-1 immunotherapy. The work points toward combination strategies that address tumor-intrinsic immune checkpoints. Together, the findings connect radiation delivery biology with immune suppression mechanisms—two levers increasingly being integrated into next-generation multimodality oncology regimens.