A study in advanced science connects tumor-secreted LRG1 to neutrophil mitochondrial dysfunction and NET release, describing a pathway that destabilizes tumor vessels and undermines chemo-immunotherapy in bladder cancer. In colorectal cancer, research links collagen-rich tumor matrices to TGFβ signaling and an EMT-biased plastic state that reshapes inflammatory responses to chemotherapy. Finally, a pharmacology-focused review argues that the unfolded protein response can help tumors evade immune detection, offering targets to potentially boost checkpoint inhibitor effectiveness—moving stress-signaling from correlation to intervention design.