Weill Cornell Medicine researchers reported in Cancer Cell that activated T cells secrete extracellular vesicles carrying DNA, which can enter tumor and immune cells to enhance antigen processing and presentation. In mouse studies across multiple immunologically cold tumor models, these activated T cell–derived EVs increased antigen presentation and dendritic cell activity. The same work showed that activated EVs could synergize with immune checkpoint inhibitors to suppress tumor growth and strengthen anti-tumor immunity in settings where tumors otherwise show limited immune visibility. The authors position the findings as a potential platform for an acellular immunotherapy approach that leverages an endogenous immune feedback mechanism. David Lyden, MD, PhD, co-senior author, framed the results as evidence of a natural pathway that can restore immune surveillance by improving antigen presentation capacity.