University of Pittsburgh-led researchers identified clinical blood concentration cutoffs for the brain proteins GFAP and UCH-L1 that help emergency clinicians detect intracranial pathology in traumatic brain injury patients, including abnormalities that CT scans miss. The work focuses on practical thresholds that can be used in acute settings. In emergency medicine, CT limitations can leave clinicians with uncertainty when symptoms and risk factors indicate potential injury. The study suggests a complementary biomarker approach that could refine triage and downstream imaging decisions. The key near-term question is how these cutoffs perform across broader sites, scanners, and patient demographics—particularly in prospective impact studies.