Leaders from key genomics companies shared insights into the evolving landscape of next-generation sequencing (NGS) and multiomics. Jacob Thaysen, CEO of Illumina, outlined his vision for advancing genomics despite his outsider status to the field, emphasizing adaptation and integration of new technologies. Clive Brown, formerly of Oxford Nanopore Technologies, reflected on breakthroughs in nanopore sequencing and its future potential. These discussions, part of the GEN virtual summit, highlight ongoing innovations shaping genomics research and diagnostics.