A Nature Chemical Biology study showed intracellular delivery of multivalent Intrinsically Disordered Regions (IDRs) induces condensate formation that enhances CAR‑T cytotoxicity against low‑antigen tumor models. The mechanism increased target engagement and killing in preclinical systems, offering a potential method to improve cell‑therapy responses where antigen density is limiting. Condensation‑based modulation refers to biomolecular phase separation that concentrates signaling components; as a therapeutic strategy, it may augment existing CAR constructs but will require safety and delivery solutions before clinical translation.