Researchers reported a systematic process to produce human kidney organoids intended to advance porcine‑based xenotransplantation and regenerative‑medicine studies, publishing methods that aim to standardize organoid generation at scale. The Nature Biomedical Engineering study outlines reproducible protocols for organoid maturation and compatibility testing with porcine recipients. The work addresses the organ shortage by creating human tissue models to evaluate immune compatibility and function in large‑animal transplant models. Authors emphasize reproducibility and regulatory considerations for translating organoid‑assisted xenotransplantation into preclinical pipelines and eventual clinical testing.