Researchers developed a scalable method to produce thousands of human kidney organoids and demonstrated integration with perfused porcine kidneys ex vivo, culminating in the first transplant of porcine kidneys modified with human renal organoids. Teams from IBEC and international collaborators used normothermic perfusion machines to infuse organoids and monitor viability and engraftment in real time. The approach addresses two critical bottlenecks—uniform, high-throughput organoid production and organ-level transplantation testing—by combining human stem-cell–derived organoids with clinically relevant ex vivo organ perfusion platforms. Results were published in Nature Biomedical Engineering and highlighted at institutional releases. This work moves organoid technologies toward translational testing for drug screening and potential cell therapies, while raising questions about immunogenicity, scale-up for human use, and regulatory pathways for chimeric organ approaches.