Researchers at the Institute for Bioengineering of Catalonia and Dexeus University Hospital achieved the first ever real-time three-dimensional imaging of human embryo implantation into a collagen matrix mimicking uterine tissue. Utilizing advanced microscopy and synthetic ex vivo platforms, the team visualized the biomechanical forces exerted by embryos during uterine attachment over several days. This breakthrough offers unprecedented insights into implantation dynamics, a critical stage frequently associated with infertility and miscarriage, and could inform improvements in assisted reproductive technologies.