The Human Cell Atlas project mapped distinct fibroblast subpopulations in healthy and diseased skin via single-cell sequencing and spatial transcriptomics, uncovering six subtypes in normal tissue and three in diseased samples. Each subtype shows unique gene expression profiles and occupies specific niches, illuminating their diverse roles in tissue biology. These findings reveal promising drug targets for a range of diseases beyond dermatology, highlighting fibroblasts' contributions to pathology and therapy development.