Researchers presented converging preclinical evidence that self-assembling peptide micelles can improve antifungal therapy. A Nature Biotechnology report describes a host-defense peptide mimic that forms micelles to codeliver antifungal drugs, increasing efficacy while reducing toxicity in animal models. An independent team demonstrated polymer- or peptide-based micellar delivery systems that enable combinatorial antifungal regimens with improved tolerability. These studies highlight formulation strategies to tackle invasive fungal infections where drug toxicity and resistance constrain options.