A Nature Communications study led by Singh, Islam and Liu identified sialoglycans on the surface of HIV‑infected CD4+ T cells as a mechanism that reduces myeloid‑cell mediated clearance. The team showed infected cells upregulate specific sialylated glycans, which engage myeloid inhibitory pathways and help infected T cells evade phagocytosis. The paper suggests targeting sialylation or the lectin receptors that recognize these glycans could restore innate immune clearance of infected cells and inform reservoir‑reduction strategies.