Researchers reported a systematic ligand-diversification screen that couples rapid chemistry with cell-based functional assays to discover molecular glues that induce targeted protein degradation. The study, published in Nature Chemical Biology, screened thousands of variants and identified a compound that selectively degrades ENL, a driver protein in certain acute leukemias, reducing growth of ENL-dependent leukemia cells. The platform enables direct testing of chemical diversity in living cells and accelerates discovery of chemical inducers of proximity. The ENL degrader exemplifies how high-throughput, live-cell screening of ligand-modified libraries can yield molecular glues with therapeutic potential.