A consortium led by Georg Winter’s group reported a high‑throughput chemical diversification strategy that screens thousands of ligand variants in living cells to find molecular glues that induce targeted protein degradation. Using this platform, the team identified a compound that selectively degrades ENL, a key driver in certain acute leukemias, producing strong antiproliferative effects in ENL‑dependent cells. Published in Nature Chemical Biology under the title "High‑throughput ligand diversification to discover chemical inducers of proximity," the study couples parallel chemistry with functional cellular readouts to accelerate discovery of small molecules that reprogram protein–protein interactions for degradation. Why it matters: the method expands practical routes to molecular glue discovery, offering a scalable path to target previously undruggable oncogenic proteins through the cell’s own degradation machinery.