Chiang et al. report that urothelial cancer cells with elevated CD14 expression reshape the tumor microenvironment into a neutrophil‑rich state following radiation. The study links tumor-intrinsic CD14 signaling to recruitment and activation of neutrophils, which the authors associate with immune suppression and metastatic behavior. The work characterizes cellular and cytokine changes in irradiated tumors and discusses implications for combining radiotherapy with strategies that modulate neutrophil function or block tumor-derived CD14 pathways. The findings highlight a radiation-induced, tumor-driven immune axis that may limit the efficacy of current combined-modality regimens.