A study by Chiang et al. reported that urothelial cancers with high CD14 expression sculpt a neutrophil‑rich tumor microenvironment following radiation, which can blunt antitumor immunity and promote metastatic features. The authors linked CD14+ tumor cell signaling to neutrophil recruitment and immunosuppressive remodeling. The paper highlights a potential mechanism for radiation‑associated immune modulation and suggests targeting CD14‑mediated pathways or neutrophil recruitment as combination strategies with radiotherapy and immunotherapies. Translational work is needed to validate targets and test therapeutic inhibitors in clinical settings.