A report examines how whole-patient support models are reshaping oncology care as treatments become more personalized and patient-managed outside of clinic visits. It points to the growing complexity of regimens, where patients must coordinate oral therapies, manage comorbidities, and handle side effects while navigating logistics and financial barriers. Walgreens Specialty Pharmacy is cited for its specialty care model, including oncology-trained pharmacy teams and a multichannel support network intended to maintain adherence and reduce drop-off during therapy. The piece highlights a reported medication adherence rate of 92% compared with an industry benchmark of 80%. The operational focus—integrating clinical pharmacy, nursing, dietitians, and benefits specialists—signals how payer and provider expectations are moving toward infrastructure for adherence and outcome support rather than dispensing alone.