Groundbreaking research demonstrates that human gut bacteria can bioaccumulate per- and polyfluoroalkyl substances (PFAS), known as 'forever chemicals,' posing environmental and health concerns. Specific bacterial strains sequester PFAS intracellularly, reducing systemic exposure as shown in mouse models. This discovery opens avenues for microbiome-based detoxification strategies and calls attention to the remediation of persistent environmental pollutants with implications for chronic disease prevention.