New research presented at ESHRE reveals a compelling link between polycystic ovary syndrome (PCOS), imbalanced gut microbiota, and altered amino acid metabolism associated with increased miscarriage risk. The study highlights distinctive microbial and metabolic profiles in women with PCOS that correlate with premature cellular aging and reproductive complications. These findings suggest a novel biological pathway connecting gut microbial ecosystems with reproductive health outcomes, offering potential targets for therapeutic intervention in PCOS-associated miscarriage.