The University of British Columbia researchers have successfully transplanted a kidney converted from blood type A to universal donor type O using specialized enzymes developed over a decade. This enzyme conversion approach circumvents traditional immunosuppressive treatments by modifying the organ itself, enabling transplantation without hyperacute rejection initially. While mild immune reactions emerged after several days, damage was notably less severe than typical mismatched transplants, indicating promising tolerance development. Published in Nature Biomedical Engineering, this milestone represents a transformative step toward alleviating donor shortage and improving transplant accessibility.