Neural organoids are revolutionizing neuroscience research by enabling complex studies of human brain development, disease modeling, and therapeutic discovery previously inaccessible through animal models. Panels featuring experts from UC San Diego and University of Pennsylvania highlight the growing role of organoids in elucidating neurological disorders and advancing precision medicine goals. Concurrently, embryonic stem cell-derived spheroids offer scaffold-free cartilage engineering, enhancing regenerative medicine capabilities. These multidisciplinary innovations underscore the accelerating integration of stem-cell technologies into fundamental and translational neuroscience.