Weill Cornell Medicine and University of Adelaide researchers released GoT‑Multi, a high‑throughput single‑cell multi‑omics method compatible with FFPE samples that co‑detects multiple somatic genotypes and whole transcriptomes. The tool lets investigators map clonal evolution and transcriptional states in archived pathology specimens, enabling retrospective analyses across widely available clinical archives. In complementary work, metabolic imaging approaches were reported to track CAR‑T cell health in vivo, providing noninvasive biomarkers of T‑cell fitness and persistence. Together these advances strengthen the single‑cell and metabolic toolkits for understanding therapy resistance and optimizing cell therapies. Translational note: FFPE compatibility is critical for clinical translation because it accesses vast tissue banks; combined genotyping and transcriptomics at single‑cell resolution accelerates studies of neoplastic progression and therapy failure.