Researchers introduced GoT‑Multi, a high‑throughput single‑cell multi‑omics tool that co‑detects multiple somatic genotypes and whole transcriptomes from formalin‑fixed, paraffin‑embedded (FFPE) samples to trace clonal evolution in blood cancers. The Cell Genomics paper describes application of GoT‑Multi to chronic lymphocytic leukemia samples, revealing how slow‑growing clones can transform and acquire therapy resistance. GoT‑Multi’s compatibility with FFPE tissue expands access to archived pathology material and enables larger retrospective studies of tumor evolution, resistance mechanisms and microenvironment interactions using routinely collected clinical specimens.