Researchers at Weill Cornell Medicine and the University of Adelaide released GoT‑Multi, a high‑throughput single‑cell multi‑omics method that co‑detects multiple somatic genotypes and whole transcriptomes in formalin‑fixed, paraffin‑embedded (FFPE) tissue. The tool enables tracking of clonal evolution and transcriptional states in archived pathology samples, expanding single‑cell genotyping to widely available clinical material. GoT‑Multi was applied to leukemia samples to trace how indolent disease can transform into lymphoma, revealing clonal trajectories and transcriptional programs linked to progression and therapy resistance. The authors published the method in Cell Genomics and highlighted compatibility with routine pathology workflows. The advance matters because it lets investigators interrogate therapeutic resistance and tumor evolution retrospectively across large FFPE cohorts, accelerating translational discovery without requiring fresh tissue.