Google DeepMind has unveiled AlphaGenome, a single AI foundation model that integrates multiple predictive tasks related to genomic variants. Trained on vast datasets, AlphaGenome forecasts outcomes like gene expression, RNA splicing, chromatin accessibility, transcription factor binding, and 3D genome architecture from DNA sequences. This unified approach outperforms or matches best-in-class specialized tools on most benchmarks, streamlining variant interpretation for clinical and research settings. Experts highlight AlphaGenome’s role in synthesizing complex genomic data layers for improved biological insight.