Researchers at UC San Diego and collaborators released the GNPS Drug Library, an MS/MS reference resource linking thousands of drugs, metabolites and analogs with exposure sources, pharmacologic classes and mechanisms; the work was reported in Nature Communications. The public library enables untargeted metabolomics datasets to be queried to empirically establish drug exposure records from patient samples. Complementing the database, a new online tool now allows clinicians and researchers to detect drug exposures directly from blood or urine samples, improving case histories and drug‑interaction assessments when medical records are incomplete. Authors including Pieter Dorrestein emphasized the utility for pharmacology, toxicology, and retrospective studies. The resources could change pharmacovigilance, clinical toxicology and biomarker studies by providing empirical exposure data that supplements or corrects patient recall and medical records—especially important for polypharmacy, OTC use, and environmental exposures.