Researchers reported results from a randomized trial in Nature Communications evaluating whether renal resistive index (RRI)–guided mean arterial pressure (MAP) targets improve outcomes for critically ill sepsis patients. The study uses Doppler-derived kidney hemodynamics to individualize MAP titration versus standard approaches, aiming to shift sepsis management toward more physiology-aligned target setting. If validated in broader settings, the work could support bedside decision-making tools that translate organ-specific perfusion signals into hemodynamic targets during sepsis treatment.