A study revealed that cancer cells utilize sulfated glycosaminoglycans on their surface to mediate uptake of lipoproteins carrying α-tocopherol, a form of vitamin E that inhibits ferroptosis, an iron-dependent cell death. Disrupting this pathway sensitized tumors to ferroptosis and impaired growth in mice. Elevated levels of chondroitin sulfate and lipoprotein-derived antioxidants mark clear cell renal cell carcinoma, underscoring this mechanism as an anti-ferroptotic cancer strategy and therapeutic target.