A paper in Nature Medicine this week described Talos, an open-source automated genomic reanalysis tool designed to scale rare-disease diagnosis. Built by Australia’s Centre for Population Genomics with Australian Genomics, the Broad Institute, and Microsoft Research, Talos reanalyzed 4,735 previously unsolved patient genomes. The tool reportedly generated 241 diagnoses, with more than half linked to new gene–disease or variant–disease associations discovered after the original sequencing analyses. Reviewers highlighted the design goal: automate reanalysis so families and clinicians do not have to wait for ad hoc, manually requested updates. The report also emphasized safeguards for clinical deployment, including the need for manual review of positive outputs and restricting the analysis to high-confidence associations in PanelApp Australia and ClinVar to limit false positives.