Recent advances in genomics and multiomics are reshaping understanding of biology and disease. The 1000 Genomes Project Long-Read Sequencing Consortium expanded efforts by adding PacBio sequencing to nanopore data, deepening insight into genome structural variation. Keynotes from multiomics summits featured Illumina CEO Jacob Thaysen and other experts discussing cell mapping, proteomics, and precision oncology, as well as the evolution from the Human Genome Project. New computational approaches enable prediction of cell activity using plain-language 'hypothesis grammar,' enhancing biological modeling. These integrative efforts accelerate discovery and therapeutic innovation across biotechnology.