A new open-source automated genomic reanalysis tool called Talos can expand rare-disease diagnostic throughput, according to a study published in Nature Medicine. In tests on 4,735 individuals with previously unsolved rare diseases, Talos generated 241 diagnoses, with more than half attributed to newly discovered gene- or variant-disease links uncovered after initial sequencing analysis. The method aims to address the scalability problem in rare-disease genomics by automating reanalysis workflows that are typically manual and episodic. Talos is designed to be redeployed by institutions, with labs able to customize sensitivity and specificity settings; however, the tool still requires manual review for clinical use to manage false positives. The work could affect how diagnostic labs prioritize updates as variant interpretation evolves, potentially improving patient access to genetics-led care and clinical trial matching.