Researchers reported that a gene‑edited pig kidney functioned in a brain‑dead human recipient for 61 days, with multi‑omic and physiological monitoring documenting graft performance and host responses. The case provides a detailed translational data set on immune, physiological, and cross‑species biological interactions in clinical xenotransplantation. Investigators used a suite of genetic edits in donor pigs and applied immunosuppression and monitoring protocols to assess viability, rejection, and physiologic integration over two months. Multi‑omic analyses illuminated immune activation pathways and graft adaptation signals that will inform next‑generation engineering and perioperative management. While performed in a controlled research setting, the result advances the case for xenotransplantation as a potential solution to organ shortages; remaining hurdles include long‑term immunity, porcine endogenous retrovirus risks, manufacturing of source animals, and regulatory pathways for clinical application.